Clinical need

Surgeons and societies agree: identification can't be left to chance.

Many serious intraoperative injuries come from failing to identify a critical structure, and today's tools don't close that gap. Here is what the guidelines and literature say, in their own words.

Ureter
62.4%of ureteral injuries at hysterectomy were unrecognized during surgeryJournal of Urology · 2018
Bile duct
8.8×higher long-term mortality than expected after bile duct injury, the most common serious complication of gallbladder surgerySAGES multi-society guideline · 2020
Ureter
Up to10%of patients undergoing non-urologic abdominal and pelvic operations suffer a ureteral injuryColorectal Disease · 2021
Nerve
1.1–6.3%nerve injury rate in endoscopic spine surgery, driven by the difficulty of telling nerve roots from nearby tissueGlobal Spine Journal · 2026

What the literature says

SAGES · AHPBA · IHPBA · SSAT · EAESMulti-society practice guideline · 2020
Society
Bile duct injury (BDI) is the most common serious complication of laparoscopic cholecystectomy.
Brunt LM, et al. Surg Endosc. 2020;34(7):2827–2855 · PMID 32399938 · Bile duct
American Academy of Otolaryngology–Head and Neck SurgeryClinical practice guideline · 2013
Society
The guideline development group made a strong recommendation that the surgeon should identify the recurrent laryngeal nerve(s) during thyroid surgery.
Chandrasekhar SS, et al. Otolaryngol Head Neck Surg. 2013;148(6 Suppl):S1–37 · PMID 23733893 · Nerve
American Thyroid AssociationSurgical Affairs Committee statement · 2018
Society
Hypoparathyroidism (hypoPT) is the most common complication following bilateral thyroid operations.
Orloff LA, et al. Thyroid. 2018;28(7):830–841 · PMID 29848235 · Parathyroid
Tokyo Guidelines 2018International consensus guideline
Society
Achieving a CVS prevents the misidentification of the cystic duct and the common bile duct, which are most commonly confused.
Wakabayashi G, et al. J Hepatobiliary Pancreat Sci. 2018;25(1):73–86 · doi:10.1002/jhbp.517 · Bile duct
International Neural Monitoring Study GroupThyroid · 2021
Society
There can be significant variability in the anatomic and intraoperative characteristics of the RLN, which can impact the risk of neural injury.
Liddy W, et al. Thyroid. 2021;31(11):1730–1740 · PMID 34541890 · Nerve
Expert consensus workshopJ Cancer Res Ther · 2020
Society
Accurate localization of small pulmonary nodules has remained a big challenge in lung surgery.
Liu B, Gu C. J Cancer Res Ther. 2020;16(5):967–973 · PMID 33004736 · Nodule
JAMA Surgery2025
Nerve
There are currently no approved intraoperative agents to aid in the visual identification of nerve structures.
Gold SA, et al. JAMA Surg. 2025;160(8):875–883 · PMID 40601345
Annals of Surgery2003 · 252 bile duct injuries
Bile duct
The primary cause of error in 97% of cases was a visual perceptual illusion.
Way LW, et al. Ann Surg. 2003;237(4):460 · PMID 12677139
Colorectal Disease2021
Ureter
As we continue to broaden the application of minimally invasive surgical techniques, a new form of ureteral identification and avoidance that does not rely on tactile feedback is needed.
White LA, et al. Colorectal Dis. 2021;23(3):718–723 · PMID 33064915
The Journal of Urology2018 · population-based
Ureter
Ureteral injury occurred in 1,753 of 223,872 patients (0.78%) treated with hysterectomy and it was unrecognized in 1,094 (62.4%).
Blackwell RH, et al. J Urol. 2018;199(6):1540–1545 · PMID 29408429
Theranostics2018
Nerve
Using white light reflectance, the visual difference between nerves, especially small nerves like the autonomic nerves within the prostate, and adjacent tissue can be imperceptible.
Hingorani DV, et al. Theranostics. 2018;8:4226 · PMID 30128049
American Journal of Obstetrics & Gynecology2016
Ureter
Iatrogenic ureteral injuries, more than half of which occur during gynecologic surgery, may have devastating consequences for both patients and physicians.
Lee Z, et al. Am J Obstet Gynecol. 2016 · PMID 26519785
Journal of Clinical Endocrinology & Metabolism2014
Parathyroid
There is a critical need for an improved intraoperative method for real-time parathyroid identification.
McWade MA, et al. J Clin Endocrinol Metab. 2014;99(12):4574–4580 · PMID 25148235
Journal of the National Cancer Institute2005 · 116,995 patients
Lymph node
Only 37% of all patients received adequate lymph node evaluation.
Baxter NN, et al. J Natl Cancer Inst. 2005;97(3):219–225 · PMID 15687365
CHEST1999
Nodule
Fifty patients (54%) needed conversion to a thoracotomy. The most common reason for the conversion was failure to localize nodules (46%).
Suzuki K, et al. Chest. 1999;115(2):563–568 · PMID 10027460
British Journal of Surgery2012 · systematic review
Bile duct
There is no robust evidence to support or abandon the use of IOC to prevent retained CBD stones or bile duct injury.
Ford JA, et al. Br J Surg. 2012 · PMID 22183717
Diseases of the Colon & Rectum2017
Vessel
Surgeons must watch, observe, and bear in mind that vascular variations can occur. Awareness of these complex variations may improve the quality of surgery and may prevent devastating complications during right-sided colon resections.
Kuzu MA, et al. Dis Colon Rectum. 2017;60(3):290–298 · PMID 28177991
The Annals of Thoracic Surgery2014
Nodule
Small nodules are frequently missed or difficult to find despite preoperative imaging.
Okusanya OT, et al. Ann Thorac Surg. 2014;98(4):1223–1230 · PMID 25106680
Surgical Endoscopy2018
Ureter
Ureteric stents are utilised as a method to reduce the risk of injury; however, these are not without risk and do not guarantee prevention of injury.
Barnes TG, et al. Surg Endosc. 2018;32(9):4036–4043 · PMID 29785456
World Journal of Gastrointestinal Surgery2023
Vessel
Bleeding complications due to vascular injuries represent an important cause of morbidity and mortality, especially when facing major bleeding during laparoscopy, where bleeding control can be technically challenging in inexperienced hands.
Pesce A, et al. World J Gastrointest Surg. 2023;15(3):338–345 · PMID 37032796
Global Spine Journal2026
Spine · MKR
The incidence of nerve injury in endoscopic spinal surgery ranges from 1.1% to 6.3%, primarily due to the difficulty in distinguishing nerve roots from adjacent structures
Huang H, et al. Global Spine J. 2026;16(6):2510–2525 · PMID 41424186
Spine Surgery and Related Research2020
Spine · MKR
Unrecognized durotomy occurred in 21 cases of spinal metastasis (26.7%) and in 1 case of cervical spondylotic myelopathy (2%), representing a significant difference between groups.
Koyama T, et al. Spine Surg Relat Res. 2020;4(2):159–163 · PMID 32405563
Gastroenterology Report2016 · rectal cancer surgery
Nerve
Sexual dysfunction may also reach 11–55% after TME.
Chew M-H, et al. Gastroenterol Rep. 2016;4(3):173 · PMID 27478196

All quotations are verbatim from the cited guideline, consensus statement, or peer-reviewed article (full text or indexed abstract). Society-authored statements are highlighted. Citations link to PubMed or the publisher DOI.

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